Endocrine Abstracts

Case: A 41 year-old-Indian woman with type 2 diabetes treated with liraglutide was admitted to the Emergency Department with abdominal pain, nausea, vomiting and bloated abdomen. She was found to have raised amylase at 706 U/l. Abdominal ultrasound and CT scan did not reveal any abnormalities in the pancreas or billary tract and the patient was discharged.She had diabetes for 9 years duration treated with metformin, pioglitazone and liraglutide. Over 2 y...

Hypophysitis is a rare clinical condition manifesting as pituitary dysfunction: hypopituitarism or diabetes insipidus (DI) and pituitary enlargement causing mass effect (headaches, visual disturbances) due to the inflammation of the pituitary gland. We conducted a retrospective analysis of medical records of patients diagnosed with hypophysitis in the Department of Endocrinology of the Bielanski Hospital from 2014 to 2019. Twenty-five patients were identified, which represents...

Introduction: Studies suggest that disturbed thyroid hormones (TH) homeostasis may lead to increased cancer risk. However, the exact role of TH in cancerogenesis is unknown. We have previously identified 15 genes linked with TH signaling in 7 cancer types and 10.967 cancer patients. Here, we investigated the influence of hypothyroidism on the expression of these 15 genes in rat tissues/organs from which the previously identified, TH-related cancer types originate.<p class=...

Introduction: With the wider availability of imaging techniques there is an increasing number of newly diagnosed, accidentally found pathological formations in the adrenal glands known as adrenal incidentaloma (AI). Currently, the professional consensus is that hormonally active incidentalomas and those suspicious of malignancy should be indicated for surgery.Methods: In our retrospective study, we analyzed data of 141 patients with a total of 160 AIs, w...

Levothyroxine suppression therapy, i.e. keeping the TSH value below 0.3 mIU/l with the aim to reduce the total thyroidal tissue or nodule volume, is an arguable and controversial issue not only due to the effect upon nodule volume but also because of the extent of necessary suppression, the effect of incomplete suppression, long-time therapeutic effects and risk of cardiovascular problems and osteoporosis.The incidence of nodular alterations rises with a...

Introduction: Scintigraphy had long been the only modality for thyroid gland imaging. With the development of other imaging techniques (sonography, CT, MRI), the role of scintigraphy has gradually diminished. However, it cannot be completely ignored, as it is the only technique to image not only the morphological structure, but also the functional status of the thyroid gland. In the current clinical practice, thyroid scintigraphy is performed with 99mTc pertechnetat...

Cushing’s syndrome is associated with life-threatening complications, as well as high rates of perioperative mortality and morbidity. Authors present clinical scenarios, in which one should consider the usage of intravenous etomidate as an accurate, safe and effective drug for hypercortisolaemia.Case 1: 23-year-old female with severe Cushing’s syndrome due to metastatic adrenocortical carcinoma was admitted to the Department of Endocrinology. S...

Back groundBoth pregnancy and polycystic ovary syndrome (PCOS) constitute insulin-resistant states, while gestational diabetes (GDM) is associated with adverse pregnancy outcomes. Though screening for GDM is typically performed later in pregnancy, some women demonstrate significant insulin resistance (IR) and develop GDM even in 1st trimester. We have endeavoured to compare surrogate IR indices in 1st trimester pregnant women and in...

Background2–3% of the general population is chronically treated with glucocorticoids (GCs). Modification of the structure and/or function of the glucocorticoid receptor (GR) due to its polymorphisms may result in increased (GC – S – bclI, N363S) or decreased (GC – I – A3669G, ER22/23EK) sensitivity to GCs. To date, whether such modulation of cell’s response to GCs can be associated with presence or absence of the side effect...

Introduction: Substrate accumulation, energy deficiency or complex molecule defects characterize inherited metabolic disorders (IMDs), accounting for their multi-system manifestations. One important aspect of this is endocrinopathy, which is relatively common but underestimated in IMDs, presenting in childhood following diagnosis or sometimes a presenting symptom in adults where there is multi-system or multi-gland involvement. Endocrinopathies may be secondar...